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Vaccine-Associated Measles Encephalitis in Immunocompromised Child, California, USA.

ABSTRACT: We report a fatal case of vaccine-associated measles encephalitis in an immunocompromised child in California, USA. The infection was confirmed by whole-genome RNA sequencing of measles virus from brain tissue. We observed biased matrix-gene hypermutation consistent with persistent measles virus central nervous system infection.

SUBMITTER: Costales C 

PROVIDER: S-EPMC8962891 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Vaccine-Associated Measles Encephalitis in Immunocompromised Child, California, USA.

Costales Cristina C   Sahoo Malaya K MK   Huang ChunHong C   Guimaraes Carolina V CV   Born Donald D   Kushner Lauren L   Gans Hayley A HA   Doan Thuy A TA   Pinsky Benjamin A BA  

Emerging infectious diseases 20220401 4

We report a fatal case of vaccine-associated measles encephalitis in an immunocompromised child in California, USA. The infection was confirmed by whole-genome RNA sequencing of measles virus from brain tissue. We observed biased matrix-gene hypermutation consistent with persistent measles virus central nervous system infection. ...[more]

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