RNA Virus Gene Signatures Detected in Patients With Cardiomyopathy After Chemotherapy; A Pilot Study.

ABSTRACT:

Background

Viral infections are pervasive and leading causes of myocarditis. Immune-suppression after chemotherapy increases opportunistic infections, but the incidence of virus-induced myocarditis is unknown.

Objective

An unbiased, blinded screening for RNA viruses was performed after chemotherapy with correlation to cardiac function.

Methods

High-throughput sequencing of RNA isolated from blood samples was analyzed following chemotherapy for hematological malignancies (N = 28) and compared with left ventricular ejection fraction (LVEF).

Results

On initial rigorous analysis, low levels of influenza orthomyxovirus and avian paramyxovirus sequences were detectable, but without significant correlation to LVEF (r = 0.208). A secondary broad data mining anal

SUBMITTER: Varkoly K 

PROVIDER: S-EPMC8962958 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature