Lanthanide-dependent coordination interactions in lanmodulin: a 2D IR and molecular dynamics simulations study.

ABSTRACT: The biological importance of lanthanides, and the early lanthanides (La³⁺-Nd³⁺) in particular, has only recently been recognized, and the structural principles underlying selective binding of lanthanide ions in biology are not yet well established. Lanmodulin (LanM) is a novel protein that displays unprecedented affinity and selectivity for lanthanides over most other metal ions, with an uncommon preference for the early lanthanides. Its utilization of EF-hand motifs to bind lanthanides, rather than the Ca²⁺ typically recognized by these motifs in other proteins, has led it to be used as a model system to understand selective lanthanide recognition. Two-dimensional infrared (2D IR) spectroscopy combined with molecular dynamics simulations were used to inves

SUBMITTER: Liu S 

PROVIDER: S-EPMC8963139 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature