Multi-parametric functional imaging of cell cultures and tissues with a CMOS microelectrode array.

ABSTRACT: Electrode-based impedance and electrochemical measurements can provide cell-biology information that is difficult to obtain using optical-microscopy techniques. Such electrical methods are non-invasive, label-free, and continuous, eliminating the need for fluorescence reporters and overcoming optical imaging's throughput/temporal resolution limitations. Nonetheless, electrode-based techniques have not been heavily employed because devices typically contain few electrodes per well, resulting in noisy aggregate readouts. Complementary metal-oxide-semiconductor (CMOS) microelectrode arrays (MEAs) have sometimes been used for electrophysiological measurements with thousands of electrodes per well at sub-cellular pitches, but only basic impedance mappings of cell attachment have been performed

SUBMITTER: Abbott J 

PROVIDER: S-EPMC8963257 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature