LLPSDB v2.0: an updated database of proteins undergoing liquid-liquid phase separation in vitro.

ABSTRACT:

Summary

Emerging evidences have suggested that liquid-liquid phase separation (LLPS) of proteins plays a vital role both in a wide range of biological processes and in related diseases. Whether a protein undergoes phase separation not only is determined by the chemical and physical properties of biomolecule themselves, but also is regulated by environmental conditions such as temperature, ionic strength, pH, as well as volume excluded by other macromolecules. A web accessible database LLPSDB was developed recently by our group, in which all the proteins involved in LLPS in vitro as well as corresponding experimental conditions were curated comprehensively from published literatures. With the rapid increase of investigations in biomolecular LLPS and growing popularity of LLPSDB, we

SUBMITTER: Wang X 

PROVIDER: S-EPMC8963276 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature