Accelerated decline in white matter microstructure in subsequently impaired older adults and its relationship with cognitive decline.

ABSTRACT: Little is known about a longitudinal decline in white matter microstructure and its associations with cognition in preclinical dementia. Longitudinal diffusion tensor imaging and neuropsychological testing were performed in 50 older adults who subsequently developed mild cognitive impairment or dementia (subsequently impaired) and 200 cognitively normal controls. Rates of white matter microstructural decline were compared between groups using voxel-wise linear mixed-effects models. Associations between change in white matter microstructure and cognition were examined. Subsequently impaired individuals had a faster decline in fractional anisotropy in the right inferior fronto-occipital fasciculus and bilateral splenium of the corpus callosum. A decline in right inferior fronto-occipital fas

SUBMITTER: Shafer AT 

PROVIDER: S-EPMC8963308 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature