Vivarium: an interface and engine for integrative multiscale modeling in computational biology.

ABSTRACT:

Motivation

This article introduces Vivarium-software born of the idea that it should be as easy as possible for computational biologists to define any imaginable mechanistic model, combine it with existing models and execute them together as an integrated multiscale model. Integrative multiscale modeling confronts the complexity of biology by combining heterogeneous datasets and diverse modeling strategies into unified representations. These integrated models are then run to simulate how the hypothesized mechanisms operate as a whole. But building such models has been a labor-intensive process that requires many contributors, and they are still primarily developed on a case-by-case basis with each project starting anew. New software tools that streamline the integrative modeling ef

SUBMITTER: Agmon E 

PROVIDER: S-EPMC8963310 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature