Telogator: a method for reporting chromosome-specific telomere lengths from long reads.

ABSTRACT:

Motivation

Telomeres are the repetitive sequences found at the ends of eukaryotic chromosomes and are often thought of as a 'biological clock,' with their average length shortening during division in most cells. In addition to their association with senescence, abnormal telomere lengths are well known to be associated with multiple cancers, short telomere syndromes and as risk factors for a broad range of diseases. While a majority of methods for measuring telomere length will report average lengths across all chromosomes, it is known that aberrations in specific chromosome arms are biomarkers for certain diseases. Due to their repetitive nature, characterizing telomeres at this resolution is prohibitive for short read sequencing approaches, and is challenging still even with longe

SUBMITTER: Stephens Z 

PROVIDER: S-EPMC8963315 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature