DisEnrich: database of enriched regions in human dark proteome.

ABSTRACT:

Motivation

Intrinsically disordered proteins (IDPs) are involved in numerous processes crucial for living organisms. Bias in amino acid composition of these proteins determines their unique biophysical and functional features. Distinct intrinsically disordered regions (IDRs) with compositional bias play different important roles in various biological processes. IDRs enriched in particular amino acids in human proteome have not been described consistently.

Results

We developed DisEnrich-the database of human proteome IDRs that are significantly enriched in particular amino acids. Each human protein is described using Gene Ontology (GO) function terms, disorder prediction for the full-length sequence using three methods, enriched IDR composition and ranks of human proteins wit

SUBMITTER: Medvedev KE 

PROVIDER: S-EPMC8963327 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature