Diagnostic Accuracy of Blood-Based Biomarker Panels: A Systematic Review.

ABSTRACT:

Background

Because of high prevalence of Alzheimer's disease (AD) in low- and middle-income countries (LMICs), there is an urgent need for inexpensive and minimally invasive diagnostic tests to detect biomarkers in the earliest and asymptomatic stages of the disease. Blood-based biomarkers are predicted to have the most impact for use as a screening tool and predict the onset of AD, especially in LMICs. Furthermore, it has been suggested that panels of markers may perform better than single protein candidates.

Methods

Medline/Pubmed was searched to identify current relevant studies published from January 2016 to December 2020. We included all full-text articles examining blood-based biomarkers as a set of protein markers or panels to aid in AD's early diagnosis, prognosis, a

SUBMITTER: Hardy-Sosa A 

PROVIDER: S-EPMC8963375 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature