Recovery of serum testosterone levels is an accurate predictor of survival from COVID-19 in male patients.

ABSTRACT:

Background

SARS-CoV-2 infection portends a broad range of outcomes, from a majority of asymptomatic cases to a lethal disease. Robust correlates of severe COVID-19 include old age, male sex, poverty, and co-morbidities such as obesity, diabetes, and cardiovascular disease. A precise knowledge of the molecular and biological mechanisms that may explain the association of severe disease with male sex is still lacking. Here, we analyzed the relationship of serum testosterone levels and the immune cell skewing with disease severity in male COVID-19 patients.

Methods

Biochemical and hematological parameters of admission samples in 497 hospitalized male and female COVID-19 patients, analyzed for associations with outcome and sex. Longitudinal (in-hospital course) analyses of a sub

SUBMITTER: Toscano-Guerra E 

PROVIDER: S-EPMC8963401 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature