Effects of Atrial Fibrillation on the Human Ventricle.

ABSTRACT:

Rationale

Atrial fibrillation (AF) and heart failure often coexist, but their interaction is poorly understood. Clinical data indicate that the arrhythmic component of AF may contribute to left ventricular (LV) dysfunction.

Objective

This study investigates the effects and molecular mechanisms of AF on the human LV.

Methods and results

Ventricular myocardium from patients with aortic stenosis and preserved LV function with sinus rhythm or rate-controlled AF was studied. LV myocardium from patients with sinus rhythm and patients with AF showed no differences in fibrosis. In functional studies, systolic Ca²⁺ transient amplitude of LV cardiomyocytes was reduced in patients with AF, while diastolic Ca²⁺ levels and Ca²⁺ transient kinetics w

SUBMITTER: Pabel S 

PROVIDER: S-EPMC8963444 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature