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Long COVID Through a Public Health Lens: An Umbrella Review.


ABSTRACT: Objectives: To synthesize existing evidence on prevalence as well as clinical and socio-economic aspects of Long COVID. Methods: An umbrella review of reviews and a targeted evidence synthesis of their primary studies, including searches in four electronic databases, reference lists of included reviews, as well as related article lists of relevant publications. Results: Synthesis included 23 reviews and 102 primary studies. Prevalence estimates ranged from 7.5% to 41% in non-hospitalized adults, 2.3%-53% in mixed adult samples, 37.6% in hospitalized adults, and 2%-3.5% in primarily non-hospitalized children. Preliminary evidence suggests that female sex, age, comorbidities, the severity of acute disease, and obesity are associated with Long COVID. Almost 50% of primary studies reported some degree of Long COVID-related social and family-life impairment, long absence periods off work, adjusted workloads, and loss of employment. Conclusion: Long COVID will likely have a substantial public health impact. Current evidence is still heterogeneous and incomplete. To fully understand Long COVID, well-designed prospective studies with representative samples will be essential.

SUBMITTER: Nittas V 

PROVIDER: S-EPMC8963488 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Long COVID Through a Public Health Lens: An Umbrella Review.

Nittas Vasileios V   Gao Manqi M   West Erin A EA   Ballouz Tala T   Menges Dominik D   Wulf Hanson Sarah S   Puhan Milo Alan MA  

Public health reviews 20220315


<b>Objectives:</b> To synthesize existing evidence on prevalence as well as clinical and socio-economic aspects of Long COVID. <b>Methods:</b> An umbrella review of reviews and a targeted evidence synthesis of their primary studies, including searches in four electronic databases, reference lists of included reviews, as well as related article lists of relevant publications. <b>Results:</b> Synthesis included 23 reviews and 102 primary studies. Prevalence estimates ranged from 7.5% to 41% in non  ...[more]

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