The role of cell geometry and cell-cell communication in gradient sensing.

ABSTRACT: Cells can measure shallow gradients of external signals to initiate and accomplish a migration or a morphogenetic process. Recently, starting from mathematical models like the local-excitation global-inhibition (LEGI) model and with the support of empirical evidence, it has been proposed that cellular communication improves the measurement of an external gradient. However, the mathematical models that have been used have over-simplified geometries (e.g., they are uni-dimensional) or assumptions about cellular communication, which limit the possibility to analyze the gradient sensing ability of more complex cellular systems. Here, we generalize the existing models to study the effects on gradient sensing of cell number, geometry and of long- versus short-range cellular communication in 2D s

SUBMITTER: Fiorentino J 

PROVIDER: S-EPMC8963572 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature