Association Between Postillumination Pupil Response and Glaucoma Severity: A Cross-Sectional Analysis of the LIGHT Study.

ABSTRACT:

Purpose

This study determines whether the functional and structural severity of glaucoma is associated with intrinsically photosensitive retinal ganglion cell (ipRGC) function.

Methods

This cross-sectional study assessed 148 eyes from 148 patients with glaucoma (mean age 70.5 years). The ipRGC function was assessed by postillumination pupil response (PIPR) using the pupil diameter after exposure to blue and red light. Main outcome measures were as follows: six-second PIPR amplitude, net PIPR, and net PIPR change. Functional and structural glaucoma severities were evaluated using visual field mean deviation (MD) and the circumpapillary retinal nerve fiber layer (RNFL) thickness, respectively.

Results

Multivariable analysis adjusting for age, sex, body mass index, hyper

SUBMITTER: Yoshikawa T 

PROVIDER: S-EPMC8963668 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature