Maximum likelihood pandemic-scale phylogenetics.

ABSTRACT: Phylogenetics plays a crucial role in the interpretation of genomic data¹. Phylogenetic analyses of SARS-CoV-2 genomes have allowed the detailed study of the virus's origins², of its international^3,4 and local^4-9 spread, and of the emergence¹⁰ and reproductive success¹¹ of new variants, among many applications. These analyses have been enabled by the unparalleled volumes of genome sequence data generated and employed to study and help contain the pandemic¹². However, preferred model-based phylogenetic approaches including maximum likelihood and Bayesian methods, mostly based on Felsenstein's 'pruning' algorithm^13,14, cannot scale to the size of the datasets from the current pandemic^4,15, hamp

SUBMITTER: De Maio N 

PROVIDER: S-EPMC8963701 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature