The Induced Immune Response in Patients With Infectious Spondylodiscitis: A Prospective Observational Cohort Study.

ABSTRACT:

Introduction

Infectious spondylodiscitis is a rare infection of the intervertebral disc and the adjacent vertebral bodies that often disseminates and requires long-term antibiotic therapy. Immunologic profiling of patients with infectious spondylodiscitis could allow for a personalized medicine strategy. We aimed to examine the induced immune response in patients with infectious spondylodiscitis during and after antibiotic therapy. Furthermore, we explored potential differences in the induced immune response depending on the causative pathogen and the dissemination of the disease.

Methods

This was a prospective observational cohort study that enrolled patients with infectious spondylodiscitis between February 2018 and August 2020. A blood sample was collected at baseline, af

SUBMITTER: Loft JA 

PROVIDER: S-EPMC8963848 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature