Integrated Analysis Highlights the Immunosuppressive Role of TREM2⁺ Macrophages in Hepatocellular Carcinoma.

ABSTRACT: Recently, attention has been focused on the central role of TREM2 in diverse pathologies. However, the role of TREM2 signaling in the tumor microenvironment of hepatocellular carcinoma (HCC) remains poorly understood. Herein, we systematically investigated the single-cell transcriptomes of human HCC tissues and found that TREM2 was predominantly expressed by a macrophage subpopulation enriched in tumor tissues that resemble lipid-associated macrophages (LAMs). The accumulation of TREM2⁺ LAM-like cells in HCC was confirmed in two additional cohorts using scRNA-seq analysis and immunohistochemistry. High expression of TREM2 correlated with high infiltrating macrophage abundance and poor prognosis. Based on systematic interrogations of transcriptional profiles and cellular i

SUBMITTER: Zhou L 

PROVIDER: S-EPMC8963870 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature