Macrophage network dynamics depend on haptokinesis for optimal local surveillance.

ABSTRACT: Macrophages are key immune cells with important roles for tissue surveillance in almost all mammalian organs. Cellular networks made up of many individual macrophages allow for optimal removal of dead cell material and pathogens in tissues. However, the critical determinants that underlie these population responses have not been systematically studied. Here, we investigated how cell shape and the motility of individual cells influences macrophage network responses in 3D culture settings and in mouse tissues. We show that surveying macrophage populations can tolerate lowered actomyosin contractility, but cannot easily compensate for a lack of integrin-mediated adhesion. Although integrins were dispensable for macrophage chemotactic responses, they were crucial to control cell movement and p

SUBMITTER: Paterson N 

PROVIDER: S-EPMC8963880 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature