Isoforms of the Papillomavirus Major Capsid Protein Differ in Their Ability to Block Viral Spread and Tumor Formation.

ABSTRACT: Notably, the majority of papillomaviruses associated with a high cancer risk have the potential to translate different isoforms of the L1 major capsid protein. In an infection model, the cutaneous Mastomys natalensis papillomavirus (MnPV) circumvents the humoral immune response of its natural host by first expressing a 30 amino acid extended L1 isoform (L1_LONG). Although inducing a robust seroconversion, the raised antibodies are not neutralizing in vitro. In contrast, neutralizing antibodies induced by the capsid-forming isoform (L1_SHORT) appear delayed by several months. We now provide evidence that, although L1_LONG vaccination showed a strong seroconversion, these antibodies were not protective. As a consequence, virus-free animals subseque

SUBMITTER: Hasche D 

PROVIDER: S-EPMC8964102 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature