Casual Associations and Shape Between Prepuberty Body Mass Index and Early Onset of Puberty: A Mendelian Randomization and Dose-Response Relationship Analysis.

ABSTRACT:

Background

There is an ongoing controversial issue regarding whether onset of puberty is related to childhood BMI.

Objectives

This study aims at investigating the causal association and its shape between prepuberty BMI and early puberty onset.

Methods

Breast development and testicular volume were assessed annually from a population-based prospective cohort of 997 children for consecutive years by professional endocrinologists. Seventeen puberty- and BMI-related SNPs were selected to calculate the polygenic risk score. The two-stage least square method was used to assess and confirm causal effects. A dose-response association between prepuberty BMI and early puberty onset was conducted by using restricted cubic spline Cox regression.

Results

After adjusting for

SUBMITTER: Fang J 

PROVIDER: S-EPMC8964141 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature