E-Test or Agar Dilution for Metronidazole Susceptibility Testing of Helicobacter pylori: Importance of the Prevalence of Metronidazole Resistance.

ABSTRACT:

Background

A number of studies have shown that E-test overestimated the presence of Helicobacter pylori resistance compared to agar dilution.

Objective

The purpose of this study was to explore whether E-test could be an alternative for agar dilution to detect the metronidazole susceptibility of H. pylori.

Method

E-test and agar dilution were used to assess the susceptibility of H. pylori to metronidazole, clarithromycin, and levofloxacin in 281 clinical isolates obtained from China where the resistance was high. Cohen's kappa analysis, McNemar's test, and essential and categorical agreement analysis were performed for these two methods.

Results

Overall, the result of the E-test showed a similar prevalence of resi

SUBMITTER: Chen J 

PROVIDER: S-EPMC8964178 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature