A Longitudinal Comparison of the Recovery Patterns of Optic Neuritis with MOG Antibody-Seropositive and AQP4 Antibody-Seropositive or -Seronegative for Both Antibodies.

ABSTRACT: In this study, the aim is to compare the recovery pattern among patients with acute myelin oligodendrocyte glycoprotein antibody-seropositive optic neuritis (MOG-Ab + ON) attacks and aquaporin-4 antibody-seropositive ON (AQP4-Ab + ON) or -seronegative ON. At the onset of the first-ever ON attack, the thickness of RNFL (RNFLt) in the MOG-Ab + ON group was significantly thicker than others (P < 0.05), while visual function damage was not significantly different to other groups. One month to six months after onset, the MOG-Ab + ON group showed significantly better visual function (P < 0.05) than the other two groups, while the RNFLt showed no significant difference among the three groups (P > 0.05). MOG-Ab + ON and AQP4-Ab + ON groups showed rapid recovery in the first mo

SUBMITTER: Zhou L 

PROVIDER: S-EPMC8964224 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature