The Role of von Willebrand Factor Antigen in Predicting Survival of Patients with HBV-Related Cirrhosis.

ABSTRACT:

Objective

The model for end-stage liver disease (MELD) scoring system cannot be used to assess the deterioration of patients with liver cirrhosis caused by infection and portal hypertension. Elevated von Willebrand factor antigen (vWF-Ag) in plasma is associated with portal pressure and complications in patients with liver cirrhosis. We aimed to evaluate whether the addition of vWF-Ag can improve the risk prediction ability of the MELD scoring system.

Methods

A total of 228 patients with hepatitis B virus (HBV)-related liver cirrhosis were eligible for inclusion in this retrospective study. The vWF-Ag level was assessed by enzyme-linked immunosorbent assay (ELISA). The endpoint of this study was defined as the time to liver transplantation or death. Univariate and multivaria

SUBMITTER: Pan Y 

PROVIDER: S-EPMC8964228 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature