Sustained Downregulation of Vascular Smooth Muscle Acta2 After Transient Angiotensin II Infusion: A New Model of "Vascular Memory".

ABSTRACT:

Background

Activation of the renin-angiotensin-aldosterone system (RAAS) plays a critical role in the development of hypertension. Published evidence on a putative "memory effect" of AngII on the vascular components is however scarce.

Aim

To evaluate the long-term effects of transient exposure to AngII on the mouse heart and the arterial tissue.

Methods

Blood pressure, cardiovascular tissue damage and remodeling, and systemic oxidative stress were evaluated in C57/B6/J mice at the end of a 2-week AngII infusion (AngII); 2 and 3 weeks after the interruption of a 2-week AngII treatment (AngII+2W and AngII +3W; so-called "memory" conditions) and control littermate (CTRL). RNAseq profiling of aortic tissues was used to identify po

SUBMITTER: Pothen L 

PROVIDER: S-EPMC8964264 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature