Switching to the cyclic pentose phosphate pathway powers the oxidative burst in activated neutrophils.

ABSTRACT: Neutrophils are cells at the frontline of innate immunity that can quickly activate effector functions to eliminate pathogens upon stimulation. However, little is known about the metabolic adaptations that power these functions. Here we show rapid metabolic alterations in neutrophils upon activation, particularly drastic reconfiguration around the pentose phosphate pathway, which is specifically and quantitatively coupled to an oxidative burst. During this oxidative burst, neutrophils switch from glycolysis-dominant metabolism to a unique metabolic mode termed 'pentose cycle', where all glucose-6-phosphate is diverted into oxidative pentose phosphate pathway and net flux through upper glycolysis is reversed to allow substantial recycling of pentose phosphates. This reconfiguration maximize

SUBMITTER: Britt EC 

PROVIDER: S-EPMC8964420 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature