Associations between biomarkers of multimorbidity burden and mortality risk among patients with acute dyspnea.

ABSTRACT: The patients' burden of comorbidities is a cornerstone in risk assessment, clinical management and follow-up. The aim of this study was to evaluate if biomarkers associated with comorbidity burden can predict outcome in acute dyspnea patients. We included 774 patients with dyspnea admitted to an emergency department and measured 80 cardiovascular protein biomarkers in serum collected at admission. The number of comorbidities for each patient were added, and a multimorbidity score was created. Eleven of the 80 biomarkers were independently associated with the multimorbidity score and their standardized and weighted values were summed into a biomarker score of multimorbidities. The biomarker score and the multimorbidity score, expressed per standard deviation increment, respectively, were re

SUBMITTER: Wessman T 

PROVIDER: S-EPMC8964555 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature