Calcium Imaging and Electrophysiology of hippocampal Activity under Anesthesia and natural Sleep in Mice.

ABSTRACT: The acute effects of anesthesia and their underlying mechanisms are still not fully understood. Thus, comprehensive analysis and efficient generalization require their description in various brain regions. Here we describe a large-scale, annotated collection of 2-photon calcium imaging data and multi-electrode, extracellular electrophysiological recordings in CA1 of the murine hippocampus under three distinct anesthetics (Isoflurane, Ketamine/Xylazine and Medetomidine/Midazolam/Fentanyl), during natural sleep, and wakefulness. We cover several aspects of data quality standardization and provide a set of tools for autonomous validation, along with analysis workflows for reuse and data exploration. The datasets described here capture various aspects of neural activity in hundreds of pyramida

SUBMITTER: Formozov A 

PROVIDER: S-EPMC8964694 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature