Altered electrical properties in skeletal muscle of mice with glycogen storage disease type II.

ABSTRACT: Electrical impedance methods, including electrical impedance myography, are increasingly being used as biomarkers of muscle health since they measure passive electrical properties of muscle that alter in disease. One disorder, Pompe Disease (Glycogen storage disease type II (GSDII)), remains relatively unstudied. This disease is marked by dramatic accumulation of intracellular myofiber glycogen. Here we assessed the electrical properties of skeletal muscle in a model of GSDII, the Pompe^6neo/6neo (Pompe) mouse. Ex vivo impedance measurements of gastrocnemius (GA) were obtained using a dielectric measuring cell in 30-week-old female Pompe (N = 10) and WT (N = 10) mice. Longitudinal and transverse conductivity, σ, and the relative permittivity, ε_r, and Cole-Cole complex

SUBMITTER: Nagy JA 

PROVIDER: S-EPMC8964715 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature