Different Spatial and Temporal Roles of Monocytes and Monocyte-Derived Cells in the Pathogenesis of an Imiquimod Induced Lupus Model.

ABSTRACT: Mounting evidence indicates the importance of aberrant Toll-like receptor 7 (TLR7) signaling in the pathogenesis of systemic lupus erythematosus (SLE). However, the mechanism of disease progression remains unclear. An imiquimod (IMQ)-induced lupus model was used to analyze the lupus mechanism related to the aberrant TLR7 signals. C57BL/6 mice and NZB/NZW mice were treated with topical IMQ, and peripheral blood, draining lymph nodes, and kidneys were analyzed focusing on monocytes and monocyte-related cells. Monocytes expressed intermediate to high levels of TLR7, and the long-term application of IMQ increased Ly6C^lo monocytes in the peripheral blood and Ly6C^lo monocyte-like cells in the lymph nodes and kidneys, whereas Ly6C^hi monocyte-like cell numbers were

SUBMITTER: Nomura A 

PROVIDER: S-EPMC8964788 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature