The "WWHow" Concept for Prospective Categorization of Post-operative Severity Assessment in Mice and Rats.

ABSTRACT: The prospective severity assessment in animal experiments in the categories' non-recovery, mild, moderate, and severe is part of each approval process and serves to estimate the harm/benefit. Harms are essential for evaluating ethical justifiability, and on the other hand, they may represent confounders and effect modifiers within an experiment. Catalogs and guidelines provide a way to assess the experimental severity prospectively but are limited in adaptation due to their nature of representing particular examples without clear explanations of the assessment strategies. To provide more flexibility for current and future practices, we developed the modular Where-What-How (WWHow) concept, which applies findings from pre-clinical studies using surgical-induced pain models in mice and rats t

SUBMITTER: Tappe-Theodor A 

PROVIDER: S-EPMC8964947 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature