Serial analysis of blood biomarker concentrations in dogs with pneumonia, septic peritonitis, and pyometra.

ABSTRACT:

Background

Prolonged antimicrobial drug (AMD) treatment is associated with antimicrobial resistance development. Biomarker measurement may aid treatment decision-making.

Objectives

Investigate temporal changes in blood biomarker concentrations in dogs undergoing treatment for pulmonary and intra-abdominal infections; compare time to biomarker concentration normalization with duration of clinician-directed AMD treatment.

Animals

Forty-two client-owned dogs with pneumonia (n = 22), septic peritonitis (n = 10), or pyometra (n = 10).

Methods

Plasma concentrations of C-reactive protein (CRP), serum amyloid A (SAA), haptoglobin, procalcitonin, nucleosomes, cell-free DNA (cfDNA), high-mobility group box-1 (HMGB1), CC-motif chemokine ligand-2 (CCL2), CXC-motif chemokin

SUBMITTER: Goggs R 

PROVIDER: S-EPMC8965213 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature