NETosis and SARS-COV-2 infection related thrombosis: a narrative review.

ABSTRACT:

Background

Coronavirus disease 2019 (COVID-19) infection is related to immune hyperactivity, the release of inflammatory cytokines, and immunothrombosis. Among the underlying mechanisms in COVID-19 thrombosis, neutrophil extracellular traps (NETs) formation, NETosis, may have a significant role. COVID-19 thrombi obtained from extracorporeal membrane oxygenation contained an accumulation of neutrophils and in a higher amount of NETs when compared with non-COVID-19 thrombi specimens.

Main body

During sepsis and inflammatory status, NETs released from neutrophils and histones and nucleosomes extruded into the extracellular space and take part in the host innate immunity defense, inflammation, and thrombosis. Excessive NETosis is related to clinical progression and respiratory f

SUBMITTER: Behzadifard M 

PROVIDER: S-EPMC8965217 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature