Correlation between metabolomic profile constituents and feline pancreatic lipase immunoreactivity.

ABSTRACT:

Background

Feline pancreatic lipase immunoreactivity (fPLI) is commonly used to diagnose pancreatitis in cats (FP). Untargeted metabolomics has been extensively applied in human and veterinary medicine, but no metabolomic studies regarding FP have been conducted.

Objectives

To identify metabolites significantly associated with increased fPLI.

Animals

Forty-nine client-owned cats: 11 clinically healthy and 38 with various clinical conditions.

Methods

Analytical cross-sectional study with convenience sampling. A panel of 630 metabolites belonging to 26 biochemical classes was quantified in plasma using a commercial metabolomic assay. The correlation between plasma metabolite concentrations and serum fPLI was evaluated using Spearman's rank correlation coefficient

SUBMITTER: Krasztel MM 

PROVIDER: S-EPMC8965226 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature