Detection of blood-brain barrier dysfunction using advanced imaging methods to predict seizures in dogs with meningoencephalitis of unknown origin.

ABSTRACT:

Background

The blood-brain barrier (BBB), which separates the intravascular and neuropil compartments, characterizes the vascular bed of the brain and is essential for its proper function. Recent advances in imaging techniques have driven the development of methods for quantitative assessment of BBB permeability.

Hypothesis/objectives

Permeability of the BBB can be assessed quantitatively in dogs with meningoencephalitis of unknown origin (MUO) and its status is associated with the occurrence of seizures.

Animals

Forty dogs with MUO and 12 dogs without MUO.

Methods

Retrospective, prospective cohort study. Both dynamic contrast enhancement (DCE) and subtraction enhancement analysis (SEA) methods were used to evaluate of BBB permeability in affected (DCE, n = 8;

SUBMITTER: Hanael E 

PROVIDER: S-EPMC8965229 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature