Tenascins Interfere With Remyelination in an Ex Vivo Cerebellar Explant Model of Demyelination.

ABSTRACT: Oligodendrocytes form myelin membranes and thereby secure the insulation of axons and the rapid conduction of action potentials. Diseases such as multiple sclerosis highlight the importance of this glial cell population for brain function. In the adult brain, efficient remyelination following the damage to oligodendrocytes is compromised. Myelination is characterized by proliferation, migration, and proper integration of oligodendrocyte precursor cells (OPCs). These processes are among others controlled by proteins of the extracellular matrix (ECM). As a prominent representative ECM molecule, tenascin-C (Tnc) exerts an inhibitory effect on the migration and differentiation of OPCs. The structurally similar paralogue tenascin-R (Tnr) is known to promote the differentiation of oligodendrocyt

SUBMITTER: Bauch J 

PROVIDER: S-EPMC8965512 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature