Dynamic ⁶⁸Ga-DOTATATE PET/MRI in the Diagnosis and Management of Intracranial Meningiomas.

ABSTRACT: Purpose To evaluate dynamic gallium 68 (⁶⁸Ga) tetraazacyclododecane tetraacetic acid octreotate (DOTATATE) brain PET/MRI as an adjunct modality in meningioma, enabling multiparametric standardized uptake value (SUV) and Patlak net binding rate constant (K_i) imaging, and to optimize static acquisition period. Materials and Methods In this prospective study (ClinicalTrials.gov no. NCT04081701, DOMINO-START), ⁶⁸Ga-DOTATATE PET/MRI-derived time-activity curves (TACs) were measured in 84 volumes of interest in 19 participants (mean age, 63 years; range, 36-89 years; 13 women; 2019-2021) with meningiomas. Region- and voxel-specific K_i were determined using Patlak analysis with a validated population-based reference tissue TAC model built

SUBMITTER: Ivanidze J 

PROVIDER: S-EPMC8965533 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature