Characteristics and Clinical Significance of T-Cell Receptor Repertoire in Hepatocellular Carcinoma.

ABSTRACT: Several studies have demonstrated that the T-cell receptor (TCR) repertoire is associated with prognosis and immune therapy response in several types of cancer. However, the comprehensive features of TCR repertoire in tumor-infiltrating and circulating T cells, as well as its clinical significance of diagnosis in hepatocellular carcinoma (HCC) patients, are still unknown. In this study, we perform paired tumor/peritumoral tissues and peripheral blood samples from 58 patients with HCC and sequenced them with high-throughput TCR to comprehensively analyze the characteristics of TCR and the clinical significance of peripheral TCR sequence. By exploring the abundance and diversity of TCR repertoires, we observe that there was a significantly higher TCR diversity in peripheral blood than in tum

SUBMITTER: Wang Z 

PROVIDER: S-EPMC8965762 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature