An NIR photothermal-responsive hybrid hydrogel for enhanced wound healing.

ABSTRACT: Moderately regulating vascularization and immune microenvironment of wound site is necessary to achieve scarless wound healing of the skin. Herein, we have prepared an angiogenesis-promoting and scar-preventing band-aid with a core-shell structure, that consists of MXene-loaded nanofibers (MNFs) as the core and dopamine-hyaluronic acid hydrogel (H) as the shell (MNFs@V-H@DA) to encapsulate a growth factor (vascular endothelial growth factor, VEGF, abbreviated as V) and H₂S donor (diallyl trisulfide, DATS, abbreviated as DA). The continuous release of DA from this system produced H₂S, which would successfully induce macrophages to polarize into M2-lile phenotype, regulating the immune microenvironment and inhibiting an excessive inflammatory response at the wound sites

SUBMITTER: Jin L 

PROVIDER: S-EPMC8965777 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature