Predictors and outcomes of histological remission in ulcerative colitis treated to endoscopic healing.

ABSTRACT:

Background

Clinical remission is the recommended treatment target in ulcerative colitis. The predictors and outcomes of achieving histologic remission within a treat-to-target paradigm are not well established.

Aim

To evaluate the predictors and outcomes of achieving histologic remission in patients with ulcerative colitis treated-to-target of endoscopic healing (modified Mayo endoscopy score 0 or 1).

Methods

We conducted a retrospective cohort study in adults with active ulcerative colitis (modified Mayo endoscopy score 2 or 3), whose treatment was iteratively optimised to achieve endoscopic healing. We identified predictors of achieving histologic remission, and outcomes (risk of symptomatic relapse, and ulcerative colitis-related hospitalisation and/or surgery) of

SUBMITTER: Jangi S 

PROVIDER: S-EPMC8965793 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature