Osteogenic lithium-doped brushite cements for bone regeneration.

ABSTRACT: This study investigated the osteogenic performance of new brushite cements obtained from Li⁺-doped β-tricalcium phosphate as a promising strategy for bone regeneration. Lithium (Li⁺) is a promising trace element to encourage the migration and proliferation of adipose-derived stem cells (hASCs) and the osteogenic differentiation-related gene expression, essential for osteogenesis. In-situ X-ray diffraction (XRD) and in-situ ¹H nuclear magnetic resonance (¹H NMR) measurements proved the precipitation of brushite, as main phase, and monetite, indicating that Li⁺ favored the formation of monetite under certain conditions. Li⁺ was detected in the remaining pore solution in significant amounts after the completion of

SUBMITTER: Hurle K 

PROVIDER: S-EPMC8965853 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature