Four m6A RNA Methylation Gene Signatures and Their Prognostic Values in Lung Adenocarcinoma.

ABSTRACT: Introduction: Evidence demonstrates that N6-methyladenosine (m6A) modification plays an increasingly important role in the development of tumors. The aim of this study is to explore the expression of m6A-related regulators in lung adenocarcinoma, identify the effect of altered key factors modified by m6A on the prognosis of patients with lung adenocarcinoma. Methods: A comprehensive analysis of m6A-related gene expressions in patients with lung adenocarcinoma based on The Cancer Genome Atlas database (TCGA) and the CBioPortal database. A prognostic risk score was established based on a linear combination of 4 key gene expression levels using the regression coefficients of the multivariate Cox regression models. Immunohistochemical staining analysis was performed to validate t

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8966122 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature