Local nebulization of 1α,25(OH)₂D₃ attenuates LPS-induced acute lung inflammation.

ABSTRACT:

Background

Evidence supports a critical role of vitamin D status on exacerbation in chronic obstructive pulmonary disease, indicating the need to avoid vitamin D deficiency in these patients. However, oral vitamin D supplementation is limited by the potential risk for hypercalcemia. In this study, we investigated if local delivery of vitamin D to the lungs improves vitamin D-mediated anti-inflammatory action in response to acute inflammation without inducing hypercalcemia.

Methods

We studied vitamin D sufficient (VDS) or deficient (VDD) mice in whom 1α,25(OH)₂D₃ (0.2 μg/kg) or a vehicle followed by lipopolysaccharide (LPS 25 µg) were delivered to the lung as a micro-spray.

Results

Local 1α,25(OH)₂D₃ reduced LPS-induced infla

SUBMITTER: Serre J 

PROVIDER: S-EPMC8966160 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature