KMT2C methyltransferase domain regulated INK4A expression suppresses prostate cancer metastasis.

ABSTRACT:

Background

Frequent truncation mutations of the histone lysine N-methyltransferase KMT2C have been detected by whole exome sequencing studies in various cancers, including malignancies of the prostate. However, the biological consequences of these alterations in prostate cancer have not yet been elucidated.

Methods

To investigate the functional effects of these mutations, we deleted the C-terminal catalytic core motif of Kmt2c specifically in mouse prostate epithelium. We analysed the effect of Kmt2c SET domain deletion in a Pten-deficient PCa mouse model in vivo and of truncation mutations of KMT2C in a large number of prostate cancer patients.

Results

We show here for the first time that impaired KMT2C methyltransferase activity drives proliferation and PIN formatio

SUBMITTER: Limberger T 

PROVIDER: S-EPMC8966196 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature