Intranasal Iloprost Prevents Tumors in a Murine Lung Carcinogenesis Model.

ABSTRACT: Lung cancer chemoprevention with the prostacyclin analogue iloprost is the most promising approach to date for intercepting progression of premalignant lung lesions in former smokers. Previous preclinical studies of iloprost used oral delivery, but a study modeling delivery directly to the target organ was needed. In vivo and in vitro studies have identified gene expression changes following iloprost treatment, including increased e-cadherin and Ppargγ and decreased COX2 and vimentin. We used tumor counts and gene expression to demonstrate the effectiveness of intranasal delivery of iloprost in a murine model of premalignant adenomas. Intranasal delivery of iloprost reduced adenoma multiplicity 14 weeks after urethane exposure in FVB/N mice compared with untreat

SUBMITTER: Tennis MA 

PROVIDER: S-EPMC8966202 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature