Distribution and identification of Mycobacterium tuberculosis lineage in Kashgar prefecture.

ABSTRACT:

Objectives

Kashgar prefecture is an important transportation and trade hub with a high incidence of tuberculosis. The following study analyzed the composition and differences in Mycobacterium tuberculosis (M.tb) lineage and specific tags to distinguish the lineage of the M.tb in Kashgar prefecture, thus providing a basis for the classification and diagnosis of tuberculosis in this area.

Methods

Whole-genome sequencing (WGS) of 161 M.tb clinical strains was performed. The phylogenetic tree was constructed using Maximum Likelihood (ML) based on single nucleotide polymorphisms (SNPs) and verified through principal component analysis (PCA). The composition structure of M.tb in different regions was analyzed by combining geographic information.

Results

M.tb clinical strain

SUBMITTER: Xu AM 

PROVIDER: S-EPMC8966310 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature