Prediction of future risk of any and higher-grade prostate cancer based on the PLCO and SELECT trials.

ABSTRACT:

Background

A model was built that characterized effects of individual factors on five-year prostate cancer (PCa) risk in the Prostate, Lung, Colon, and Ovarian Cancer Screening Trial (PLCO) and the Selenium and Vitamin E Cancer Prevention Trial (SELECT). This model was validated in a third San Antonio Biomarkers of Risk (SABOR) screening cohort.

Methods

A prediction model for 1- to 5-year risk of developing PCa and Gleason > 7 PCa (HG PCa) was built on PLCO and SELECT using the Cox proportional hazards model adjusting for patient baseline characteristics. Random forests and neural networks were compared to Cox proportional hazard survival models, using the trial datasets for model building and the SABOR cohort for model evaluation. The most accurate prediction model is inclu

SUBMITTER: Gelfond JA 

PROVIDER: S-EPMC8966358 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature