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Immunotherapy in triple-negative breast cancer: A literature review and new advances.


ABSTRACT: Triple-negative breast cancer (TNBC) is a highly complex, heterogeneous disease and historically has limited treatment options. It has a high probability of disease recurrence and rapid disease progression despite adequate systemic treatment. Immunotherapy has emerged as an important alternative in the management of this malignancy, showing an impact on progression-free survival and overall survival in selected populations. In this review we focused on immunotherapy and its current relevance in the management of TNBC, including various scenarios (metastatic and early -neoadjuvant, adjuvant-), new advances in this subtype and the research of potential predictive biomarkers of response to treatment.

SUBMITTER: Valencia GA 

PROVIDER: S-EPMC8966508 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Immunotherapy in triple-negative breast cancer: A literature review and new advances.

Valencia Guillermo Arturo GA   Rioja Patricia P   Morante Zaida Z   Ruiz Rossana R   Fuentes Hugo H   Castaneda Carlos A CA   Vidaurre Tatiana T   Neciosup Silvia S   Gomez Henry L HL  

World journal of clinical oncology 20220301 3


Triple-negative breast cancer (TNBC) is a highly complex, heterogeneous disease and historically has limited treatment options. It has a high probability of disease recurrence and rapid disease progression despite adequate systemic treatment. Immunotherapy has emerged as an important alternative in the management of this malignancy, showing an impact on progression-free survival and overall survival in selected populations. In this review we focused on immunotherapy and its current relevance in  ...[more]

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