Evidence for H-bonding interactions to the μ-η²:η²-peroxide of oxy-tyrosinase that activate its coupled binuclear copper site.

ABSTRACT: The factors that control the diverse reactivity of the μ-η²:η²-peroxo dicopper(II) oxy-intermediates in the coupled binuclear copper proteins remain elusive. Here, spectroscopic and computational methods reveal H-bonding interactions between active-site waters and the μ-η²:η²-peroxide of oxy-tyrosinase, and define their effects on the Cu(II)₂O₂ electronic structure and O₂ activation.

SUBMITTER: Kipouros I 

PROVIDER: S-EPMC8966618 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature