¹⁹F-centred NMR analysis of mono-fluorinated compounds.

ABSTRACT: Addressing limitations of the existing NMR techniques for the structure determination of mono-fluorinated compounds, we have developed methodology that uses ¹⁹F as the focal point of this process. The proposed ¹⁹F-centred NMR analysis consists of a complementary set of broadband, phase-sensitive NMR experiments that utilise the substantial sensitivity of ¹⁹F and its far reaching couplings with ¹H and ¹³C to obtain a large number of NMR parameters. The assembled ¹H, ¹³C and ¹⁹F chemical shifts, values of J _HF, J _HH, and J _FC coupling constants and the size of ¹³C induced ¹⁹F isotopic shifts constitute a rich source of information

SUBMITTER: Smith AJR 

PROVIDER: S-EPMC8966657 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature